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-Structure paper
Title | Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6. |
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Journal, issue, pages | Elife, Vol. 3, Page e01998-e01998, Year 2014 |
Publish date | Nov 14, 2013 (structure data deposition date) |
Authors | Stamos, J.L. / Chu, M.L. / Enos, M.D. / Shah, N. / Weis, W.I. |
External links | PubMed:24642411 |
Methods | X-ray diffraction |
Resolution | 2.1 - 2.5 Å |
Structure data | PDB-4nm0: PDB-4nm3: PDB-4nm5: PDB-4nm7: PDB-4nu1: |
Chemicals | ChemComp-GOL: ChemComp-MG: ChemComp-ADP: ChemComp-DTT: ChemComp-CL: ChemComp-HOH: ChemComp-AF3: ChemComp-NO3: |
Source |
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Keywords | TRANSFERASE/PEPTIDE / Wnt / LRP6 / Auto-inhibited / GSK-3 / Axin / kinase / primed substrate / TRANSFERASE-PEPTIDE complex / phosphorylated N-terminal auto-inhibitory pS9 peptide / phosphorylated Wnt receptor LRP6 c-motif / phosphorylated Wnt receptor LRP6 e-motif / transition state |