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TitleStructural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody.
Journal, issue, pagesRetrovirology, Vol. 11, Page 24-24, Year 2014
Publish dateFeb 12, 2014 (structure data deposition date)
AuthorsLulf, S. / Matz, J. / Rouyez, M.C. / Jarviluoma, A. / Saksela, K. / Benichou, S. / Geyer, M.
External linksRetrovirology / PubMed:24620746
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-4orz:
HIV-1 Nef protein in complex with single domain antibody sdAb19 and an engineered Hck SH3 domain
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • hiv-1 m:b_arv2/sf2 (virus)
  • lama glama (llama)
KeywordsTRANSFERASE/APOPTOSIS/IMMUNE SYSTEM / SH3 domain / immunglobolin fold / Antibodies / Epitopes / HIV Antibodies / HIV Accessory Proteins / PxxP motif / Complementarity Determining Regions / TRANSFERASE-APOPTOSIS-IMMUNE SYSTEM complex

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