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Title | Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine series. |
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Journal, issue, pages | J. Med. Chem., Vol. 57, Page 3094-3116, Year 2014 |
Publish date | Jan 17, 2014 (structure data deposition date) |
Authors | Nishimura, N. / Norman, M.H. / Liu, L. / Yang, K.C. / Ashton, K.S. / Bartberger, M.D. / Chmait, S. / Chen, J. / Cupples, R. / Fotsch, C. ...Nishimura, N. / Norman, M.H. / Liu, L. / Yang, K.C. / Ashton, K.S. / Bartberger, M.D. / Chmait, S. / Chen, J. / Cupples, R. / Fotsch, C. / Helmering, J. / Jordan, S.R. / Kunz, R.K. / Pennington, L.D. / Poon, S.F. / Siegmund, A. / Sivits, G. / Lloyd, D.J. / Hale, C. / St Jean, D.J. |
External links | J. Med. Chem. / PubMed:24611879 |
Methods | X-ray diffraction |
Resolution | 2.4 - 2.8 Å |
Structure data | PDB-4ohk: PDB-4ohm: PDB-4oho: PDB-4ohp: |
Chemicals | ChemComp-2TE: ChemComp-S6P: ChemComp-IOD: ChemComp-GOL: ChemComp-SO4: ChemComp-HOH: ChemComp-2TF: ChemComp-2TG: ChemComp-2TJ: |
Source |
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Keywords | CARBOHYDRATE BINDING PROTEIN/INHIBITOR / Regulatory protein / Binds and inhibits GK (glucokinase) / glucokinase / nucleus / CARBOHYDRATE BINDING PROTEIN-INHIBITOR complex / SIS domain containing protein / Binds and inhibits glucokinase / liver / SIS domain / Regulatory protein - binds and inhibits Glucokinase / SIS domains / Regulatory protein - binds to and inhibits Glucokinase |