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Structure paper

TitleGeneration of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface.
Journal, issue, pagesNat. Biotechnol., Vol. 32, Page 191-198, Year 2014
Publish dateJul 9, 2013 (structure data deposition date)
AuthorsLewis, S.M. / Wu, X. / Pustilnik, A. / Sereno, A. / Huang, F. / Rick, H.L. / Guntas, G. / Leaver-Fay, A. / Smith, E.M. / Ho, C. ...Lewis, S.M. / Wu, X. / Pustilnik, A. / Sereno, A. / Huang, F. / Rick, H.L. / Guntas, G. / Leaver-Fay, A. / Smith, E.M. / Ho, C. / Hansen-Estruch, C. / Chamberlain, A.K. / Truhlar, S.M. / Conner, E.M. / Atwell, S. / Kuhlman, B. / Demarest, S.J.
External linksNat. Biotechnol. / PubMed:24463572
MethodsX-ray diffraction
Resolution1.19 - 2.16 Å
Structure data

PDB-4lld:
Structure of wild-type IgG1 antibody heavy chain constant domain 1 and light chain lambda constant domain (IgG1 CH1:Clambda) at 1.19A
Method: X-RAY DIFFRACTION / Resolution: 1.19 Å

PDB-4llm:
Structure of redesigned IgG1 first constant and lambda domains (CH1:Clambda constant redesign 1, CRD1) at 1.75A
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

PDB-4llq:
Structure of redesigned IgG1 first constant and lambda domains (CH1:Clambda constant redesign 2 beta, CRD2b) at 1.42A
Method: X-RAY DIFFRACTION / Resolution: 1.42 Å

PDB-4llu:
Structure of Pertuzumab Fab with light chain Clambda at 2.16A
Method: X-RAY DIFFRACTION / Resolution: 2.16 Å

PDB-4llw:
Crystal structure of Pertuzumab Clambda Fab with variable domain redesign (VRD2) at 1.95A
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-4lly:
Crystal structure of Pertuzumab Clambda Fab with variable and constant domain redesigns (VRD2 and CRD2) at 1.6A
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-PG6:
1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE

ChemComp-SO4:
SULFATE ION

ChemComp-ACT:
ACETATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-MG:
Unknown entry

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / IgG domain / fragment of antibody / redesign / CRD1 / IgG domain redesign / Fab

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