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Structure paper

TitleDimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity.
Journal, issue, pagesMol. Cell, Vol. 53, Page 221-234, Year 2014
Publish dateDec 16, 2013 (structure data deposition date)
AuthorsHuang, H. / Zeqiraj, E. / Dong, B. / Jha, B.K. / Duffy, N.M. / Orlicky, S. / Thevakumaran, N. / Talukdar, M. / Pillon, M.C. / Ceccarelli, D.F. ...Huang, H. / Zeqiraj, E. / Dong, B. / Jha, B.K. / Duffy, N.M. / Orlicky, S. / Thevakumaran, N. / Talukdar, M. / Pillon, M.C. / Ceccarelli, D.F. / Wan, L.C. / Juang, Y.C. / Mao, D.Y. / Gaughan, C. / Brinton, M.A. / Perelygin, A.A. / Kourinov, I. / Guarne, A. / Silverman, R.H. / Sicheri, F.
External linksMol. Cell / PubMed:24462203
MethodsX-ray diffraction
Resolution2.5 - 3.27 Å
Structure data

PDB-4o1o:
Crystal Structure of RNase L in complex with 2-5A
Method: X-RAY DIFFRACTION / Resolution: 3.27 Å

PDB-4o1p:
Crystal Structure of RNase L in complex with 2-5A and AMP-PNP
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-25L:
[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate

ChemComp-ANP:
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / AMP-PNP, energy-carrying molecule analogue*YM

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • sus scrofa (pig)
KeywordsTRANSFERASE / HYDROLASE / ankyrin repeat-kinase-RNAse / 2-5A / RNA cleavage

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