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Structure paper

TitleStructural Basis for Nuclear Import of Splicing Factors by Human Transportin 3.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 111, Page 2728-, Year 2014
Publish dateAug 6, 2013 (structure data deposition date)
AuthorsMaertens, G.N. / Cook, N.J. / Wang, W. / Hare, S. / Gupta, S.S. / Oztop, I. / Lee, K. / Pye, V.E. / Cosnefroy, O. / Snijders, A.P. ...Maertens, G.N. / Cook, N.J. / Wang, W. / Hare, S. / Gupta, S.S. / Oztop, I. / Lee, K. / Pye, V.E. / Cosnefroy, O. / Snijders, A.P. / Kewalramani, V.N. / Fassati, A. / Engelman, A. / Cherepanov, P.
External linksProc. Natl. Acad. Sci. USA / PubMed:24449914
MethodsX-ray diffraction
Resolution2.557 - 3.42 Å
Structure data

PDB-4c0o:
Transportin 3 in complex with phosphorylated ASF/SF2
Method: X-RAY DIFFRACTION / Resolution: 2.557 Å

PDB-4c0p:
Unliganded Transportin 3
Method: X-RAY DIFFRACTION / Resolution: 2.95 Å

PDB-4c0q:
Transportin 3 in complex with Ran(Q69L)GTP
Method: X-RAY DIFFRACTION / Resolution: 3.42 Å

Chemicals

ChemComp-K:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-DTT:
2,3-DIHYDROXY-1,4-DITHIOBUTANE

ChemComp-MG:
Unknown entry

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

Source
  • homo sapiens (human)
KeywordsTRANSPORT PROTEIN/RNA BINDING PROTEIN / TRANSPORT PROTEIN-RNA BINDING PROTEIN COMPLEX / NUCLEAR IMPORT / HEAT REPEAT / SPLICING FACTOR / RRM DOMAIN / RS DOMAIN / TRANSPORT PROTEIN / TNPO3 / TRANSPORT PROTEIN/GTP-BINDING PROTEIN / TRANSPORT PROTEIN-GTP-BINDING PROTEIN COMPLEX / IMPORTIN BETA

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