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TitleFamilial Alzheimer's mutations within APPTM increase A beta 42 production by enhancing accessibility of epsilon-cleavage site.
Journal, issue, pagesNat Commun, Vol. 5, Page 3037-3037, Year 2014
Publish dateSep 23, 2012 (structure data deposition date)
AuthorsChen, W. / Gamache, E. / Rosenman, D.J. / Xie, J. / Lopez, M.M. / Li, Y.M. / Wang, C.
External linksNat Commun / PubMed:24390130
MethodsNMR (solution)
Structure data

PDB-2lz3:
Solution NMR structure of transmembrane domain of amyloid precursor protein WT
Method: SOLUTION NMR

PDB-2lz4:
Solution NMR structure of transmembrane domain of amyloid precursor protein V44M
Method: SOLUTION NMR

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / helix / dimer / transmembrane

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