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Structure paper

TitleClass I Major Histocompatibility Complex, the Trojan Horse for Secretion of Amyloidogenic beta 2-Microglobulin.
Journal, issue, pagesJ. Biol. Chem., Vol. 289, Page 3318-3327, Year 2014
Publish dateJun 4, 2013 (structure data deposition date)
AuthorsHalabelian, L. / Ricagno, S. / Giorgetti, S. / Santambrogio, C. / Barbiroli, A. / Pellegrino, S. / Achour, A. / Grandori, R. / Marchese, L. / Raimondi, S. ...Halabelian, L. / Ricagno, S. / Giorgetti, S. / Santambrogio, C. / Barbiroli, A. / Pellegrino, S. / Achour, A. / Grandori, R. / Marchese, L. / Raimondi, S. / Mangione, P.P. / Esposito, G. / Al-Shawi, R. / Simons, J.P. / Speck, I. / Stoppini, M. / Bolognesi, M. / Bellotti, V.
External linksJ. Biol. Chem. / PubMed:24338476
MethodsX-ray diffraction
Resolution2.64 - 3.09 Å
Structure data

PDB-4l29:
Structure of wtMHC class I with NY-ESO1 double mutant
Method: X-RAY DIFFRACTION / Resolution: 3.09 Å

PDB-4l3c:
Structure of HLA-A2 in complex with D76N b2m mutant and NY-ESO1 double mutant
Method: X-RAY DIFFRACTION / Resolution: 2.64 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / MHC / beta-2 microglobulin / HLA_A0201 / NY-ESO1 / D76N variant / immunglobulin / beta sandwitch / amyloid aggregation

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