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-Structure paper
Title | Crystal structures of the Toll/Interleukin-1 receptor (TIR) domains from the Brucella protein TcpB and host adaptor TIRAP reveal mechanisms of molecular mimicry. |
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Journal, issue, pages | J. Biol. Chem., Vol. 289, Page 669-679, Year 2014 |
Publish date | Jul 17, 2013 (structure data deposition date) |
Authors | Snyder, G.A. / Deredge, D. / Waldhuber, A. / Fresquez, T. / Wilkins, D.Z. / Smith, P.T. / Durr, S. / Cirl, C. / Jiang, J. / Jennings, W. ...Snyder, G.A. / Deredge, D. / Waldhuber, A. / Fresquez, T. / Wilkins, D.Z. / Smith, P.T. / Durr, S. / Cirl, C. / Jiang, J. / Jennings, W. / Luchetti, T. / Snyder, N. / Sundberg, E.J. / Wintrode, P. / Miethke, T. / Xiao, T.S. |
External links | J. Biol. Chem. / PubMed:24275656 |
Methods | X-ray diffraction |
Resolution | 2.3 - 2.451 Å |
Structure data | PDB-4lqc: PDB-4lqd: |
Chemicals | ChemComp-HOH: ChemComp-GOL: |
Source |
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Keywords | IMMUNE SYSTEM / TIR / TIRAP molecular mimic / MyD88 binding / innate immunity / Flavodoxin Fold / Bacterial TIR like domain / MyD88 / Proteolytic fragment from alpha 2 chymotrypsin / Cytoplasmic / Toll-like receptor Signaling Adaptor |