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TitleThe Role of Protein Denaturation Energetics and Molecular Chaperones in the Aggregation and Mistargeting of Mutants Causing Primary Hyperoxaluria Type I
Journal, issue, pagesPlos One, Vol. 8, Page 71963-, Year 2013
Publish dateOct 22, 2012 (structure data deposition date)
AuthorsMesa-Torres, N. / Fabelo-Rosa, I. / Riverol, D. / Yunta, C. / Albert, A. / Salido, E. / Pey, A.L.
External linksPlos One / PubMed:24205397
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-2yob:
High resolution AGXT_M structure
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-PLP:
PYRIDOXAL-5'-PHOSPHATE

ChemComp-BTB:
2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / PRIMARY HYPEROXALURIA TYPE I / AGXT FOLDING AND STABILITY DEFECTS

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