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TitleT-cell receptor (TCR)-peptide specificity overrides affinity-enhancing TCR-major histocompatibility complex interactions.
Journal, issue, pagesJ. Biol. Chem., Vol. 289, Page 628-638, Year 2014
Publish dateSep 11, 2013 (structure data deposition date)
AuthorsCole, D.K. / Miles, K.M. / Madura, F. / Holland, C.J. / Schauenburg, A.J. / Godkin, A.J. / Bulek, A.M. / Fuller, A. / Akpovwa, H.J. / Pymm, P.G. ...Cole, D.K. / Miles, K.M. / Madura, F. / Holland, C.J. / Schauenburg, A.J. / Godkin, A.J. / Bulek, A.M. / Fuller, A. / Akpovwa, H.J. / Pymm, P.G. / Liddy, N. / Sami, M. / Li, Y. / Rizkallah, P.J. / Jakobsen, B.K. / Sewell, A.K.
External linksJ. Biol. Chem. / PubMed:24196962
MethodsX-ray diffraction
Resolution2.742 Å
Structure data

PDB-4mnq:
TCR-peptide specificity overrides affinity enhancing TCR-MHC interactions
Method: X-RAY DIFFRACTION / Resolution: 2.742 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • pan troglodytes (chimpanzee)
KeywordsIMMUNE SYSTEM / Surface plasmon resonance (SPR); BIAcoreTM; peptide-major histocompatibility complex (pMHC): T-cell receptor (TCR) / T-cells; high affinity TCR / two-step binding / adoptive therapy / Immunoglobulin / Adaptive immune response

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