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Structure paper

TitleStructural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 110, Page 17832-17837, Year 2013
Publish dateApr 19, 2013 (structure data deposition date)
AuthorsReshetnyak, A.V. / Nelson, B. / Shi, X. / Boggon, T.J. / Pavlenco, A. / Mandel-Bausch, E.M. / Tome, F. / Suzuki, Y. / Sidhu, S.S. / Lax, I. / Schlessinger, J.
External linksProc. Natl. Acad. Sci. USA / PubMed:24127596
MethodsX-ray diffraction
Resolution2.4 - 2.7 Å
Structure data

PDB-4k94:
Crystal structure of KIT D4D5 fragment in complex with anti-Kit antibody Fab19
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-4k9e:
Crystal structure of KIT D4D5 fragment in complex with anti-Kit antibodies Fab79D
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsIMMUNE SYSTEM / receptor tyrosine kinase (RTK) / Fab / Ig SF / IgG

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