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Structure paper

TitleCrystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly.
Journal, issue, pagesElife, Vol. 2, Page e01071-e01071, Year 2013
Publish dateJul 15, 2013 (structure data deposition date)
AuthorsCottee, M.A. / Muschalik, N. / Wong, Y.L. / Johnson, C.M. / Johnson, S. / Andreeva, A. / Oegema, K. / Lea, S.M. / Raff, J.W. / van Breugel, M.
External linksElife / PubMed:24052813
MethodsX-ray diffraction
Resolution1.7 - 2.57 Å
Structure data

PDB-4bxp:
Structure of the wild-type TCP10 domain of Danio rerio CPAP
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-4bxq:
Structure of the E1021V mutant of the TCP10 domain of Danio rerio CPAP
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-4bxr:
Structure of the wild-type TCP10 domain of Danio rerio CPAP in complex with a peptide of Danio rerio STIL
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-4by2:
SAS-4 (dCPAP) TCP domain in complex with a Proline Rich Motif of Ana2 (dSTIL) of Drosophila Melanogaster
Method: X-RAY DIFFRACTION / Resolution: 2.57 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-EDO:
1,2-ETHANEDIOL

Source
  • danio rerio (zebrafish)
  • drosophila melanogaster (fruit fly)
KeywordsCELL CYCLE / CENTRIOLE DUPLICATION / STRUCTURAL PROTEIN / CPAP / STIL / MICROCEPHALY / MCPH / CENTRIOLE / TCP DOMAIN / EXTENDED BETA SHEET

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