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Structure paper

TitleMechanism and consequence of the autoactivation of p38 alpha mitogen-activated protein kinase promoted by TAB1.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 20, Page 1182-1190, Year 2013
Publish dateJul 13, 2013 (structure data deposition date)
AuthorsDe Nicola, G.F. / Martin, E.D. / Chaikuad, A. / Bassi, R. / Clark, J. / Martino, L. / Verma, S. / Sicard, P. / Tata, R. / Atkinson, R.A. ...De Nicola, G.F. / Martin, E.D. / Chaikuad, A. / Bassi, R. / Clark, J. / Martino, L. / Verma, S. / Sicard, P. / Tata, R. / Atkinson, R.A. / Knapp, S. / Conte, M.R. / Marber, M.S.
External linksNat. Struct. Mol. Biol. / PubMed:24037507
MethodsX-ray diffraction
Resolution1.95 - 2.319 Å
Structure data

PDB-4loo:
Structural basis of autoactivation of p38 alpha induced by TAB1 (Monoclinic crystal form)
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-4lop:
Structural basis of autoactivation of p38 alpha induced by TAB1 (Tetragonal crystal form)
Method: X-RAY DIFFRACTION / Resolution: 2.049 Å

PDB-4loq:
Structural basis of autoactivation of p38 alpha induced by TAB1 (Tetragonal crystal form with bound sulphate)
Method: X-RAY DIFFRACTION / Resolution: 2.319 Å

Chemicals

ChemComp-SB4:
4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE

ChemComp-HOH:
WATER

ChemComp-TLA:
L(+)-TARTARIC ACID

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-SO4:
SULFATE ION

Source
  • mus musculus (house mouse)
KeywordsTRANSFERASE / Structural Genomics / Structural Genomics Consortium / SGC / protein kinase / kinase-regulatory protein complex / MAPK / autoactivation / autophosphorylation

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