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TitleDissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domains.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 110, Page 14924-14929, Year 2013
Publish dateFeb 26, 2013 (structure data deposition date)
AuthorsSha, F. / Gencer, E.B. / Georgeon, S. / Koide, A. / Yasui, N. / Koide, S. / Hantschel, O.
External linksProc. Natl. Acad. Sci. USA / PubMed:23980151
MethodsX-ray diffraction
Resolution2.3 - 2.31 Å
Structure data

PDB-4je4:
Crystal Structure of Monobody NSa1/SHP2 N-SH2 Domain Complex
Method: X-RAY DIFFRACTION / Resolution: 2.31 Å

PDB-4jeg:
Crystal Structure of Monobody CS1/SHP2 C-SH2 Domain Complex
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSignaling protein/protein binding / engineered binding protein / SHP2 SH2-monobody complex / Phosphatase / Phosphotyrosine Binding / Phosphorylation / Signaling protein-protein binding complex

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