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TitleNovel Hydroxyl Tricyclics (E.G., Gsk966587) as Potent Inhibitors of Bacterial Type Iia Topoisomerases.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 23, Page 5437-, Year 2013
Publish dateJun 20, 2013 (structure data deposition date)
AuthorsMiles, T.J. / Hennessy, A.J. / Bax, B. / Brooks, G. / Brown, B.S. / Brown, P. / Cailleau, N. / Chen, D. / Dabbs, S. / Davies, D.T. ...Miles, T.J. / Hennessy, A.J. / Bax, B. / Brooks, G. / Brown, B.S. / Brown, P. / Cailleau, N. / Chen, D. / Dabbs, S. / Davies, D.T. / Esken, J.M. / Giordano, I. / Hoover, J.L. / Huang, J. / Jones, G.E. / Kusalakumari Sukmar, S.K. / Spitzfaden, C. / Markwell, R.E. / Minthorn, E.A. / Rittenhouse, S. / Gwynn, M.N. / Pearson, N.D.
External linksBioorg. Med. Chem. Lett. / PubMed:23968823
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-4bul:
Novel hydroxyl tricyclics (e.g. GSK966587) as potent inhibitors of bacterial type IIA topoisomerases
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-MN:
Unknown entry

ChemComp-AE8:
(S)-4-((4-(((2,3-dihydro-[1,4]dioxino[2,3-c]pyridin-7-yl)methyl)amino)piperidin-1-yl)methyl)-3-fluoro-4-hydroxy-4H-pyrrolo[3,2,1-de][1,5]naphthyridin-7(5H)-one

ChemComp-HOH:
WATER

Source
  • staphylococcus aureus (bacteria)
  • synthetic construct (others)
KeywordsISOMERASE / TYPE IIA TOPOISOMERASES / NBTIS

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