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Structure paper

TitleA Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase.
Journal, issue, pagesBiochemistry, Vol. 52, Page 5195-5205, Year 2013
Publish dateNov 27, 2012 (structure data deposition date)
AuthorsSteussy, C.N. / Critchelow, C.J. / Schmidt, T. / Min, J.K. / Wrensford, L.V. / Burgner, J.W. / Rodwell, V.W. / Stauffacher, C.V.
External linksBiochemistry / PubMed:23802607
MethodsX-ray diffraction
Resolution1.45 - 1.85 Å
Structure data

PDB-4i4b:
HMG-CoA Reductase from Pseudomonas mevalonii complexed with NAD and intermediate hemiacetal form of HMG-CoA
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-4i56:
HMG-CoA reductase from pseudomonas mevalonii complexed with dithio-HMG-coa
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

PDB-4i64:
3-hydroxy-3-methylglutaryl Coenzyme A reductase from Pseudomonas mevalonii, a high resolution native structure
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

PDB-4i6a:
3-hydroxy-3-methylglutaryl (HMG) Coenzyme A reductase from Pseudomonas mevalonii complexed with HMG-CoA
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

PDB-4i6w:
3-hydroxy-3-methylglutaryl (HMG) Coenzyme-A reductase complexed with thiomevalonate
Method: X-RAY DIFFRACTION / Resolution: 1.66 Å

PDB-4i6y:
3-hydroxy-3-methyl (HMG) Coenzyme A Reductase bound to R-Mevalonate
Method: X-RAY DIFFRACTION / Resolution: 1.45 Å

Chemicals

ChemComp-1CV:
(3R,5R,9R,19R,21S)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,21-tetrahydroxy-8,8,21-trimethyl-10,14-dioxo-19-sulfanyl-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphatricosan-23-oic acid 3,5-dioxide

ChemComp-GOL:
GLYCEROL

ChemComp-SO4:
SULFATE ION

ChemComp-NAD:
NICOTINAMIDE-ADENINE-DINUCLEOTIDE / NAD*YM

ChemComp-1CO:
(3S)-3-hydroxy-3-methyl-5-sulfanylpentanoic acid

ChemComp-HOH:
WATER

ChemComp-1CZ:
(3S,5S,9R,21S)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,21-tetrahydroxy-8,8,21-trimethyl-10,14-dioxo-19-thioxo-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphatricosan-23-oic acid 3,5-dioxide

ChemComp-HMG:
3-HYDROXY-3-METHYLGLUTARYL-COENZYME A

ChemComp-MEV:
(R)-MEVALONATE

ChemComp-NO2:
NITRITE ION

Source
  • pseudomonas mevalonii (bacteria)
KeywordsOXIDOREDUCTASE

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