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TitleCrystallographic study of multi-drug resistant HIV-1 protease lopinavir complex: mechanism of drug recognition and resistance.
Journal, issue, pagesBiochem. Biophys. Res. Commun., Vol. 437, Page 199-204, Year 2013
Publish dateJun 3, 2013 (structure data deposition date)
AuthorsLiu, Z. / Yedidi, R.S. / Wang, Y. / Dewdney, T.G. / Reiter, S.J. / Brunzelle, J.S. / Kovari, I.A. / Kovari, L.C.
External linksBiochem. Biophys. Res. Commun. / PubMed:23792096
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-4l1a:
Crystallographic study of multi-drug resistant HIV-1 protease Lopinavir complex: mechanism of drug recognition and resistance
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-AB1:
N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE / antiretroviral, protease inhibitor*YM

ChemComp-HOH:
WATER

Source
  • human immunodeficiency virus 1
KeywordsHYDROLASE/HYDROLASE INHIBITOR / HIV-1 protease / Multi-drug resistance / IC50 / Lopinavir / protease / HYDROLASE-HYDROLASE INHIBITOR complex

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