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Structure paper

TitleStructural Evaluation of EGFR Inhibition Mechanisms for Nanobodies/VHH Domains.
Journal, issue, pagesStructure, Vol. 21, Page 1214-1224, Year 2013
Publish dateMay 16, 2013 (structure data deposition date)
AuthorsSchmitz, K.R. / Bagchi, A. / Roovers, R.C. / van Bergen En Henegouwen, P.M.P. / Ferguson, K.M.
External linksStructure / PubMed:23791944
MethodsX-ray diffraction
Resolution1.553 - 3.054 Å
Structure data

PDB-4krl:
Nanobody/VHH domain 7D12 in complex with domain III of the extracellular region of EGFR, pH 6.0
Method: X-RAY DIFFRACTION / Resolution: 2.849 Å

PDB-4krm:
Nanobody/VHH domain 7D12 in complex with domain III of the extracellular region of EGFR, pH 3.5
Method: X-RAY DIFFRACTION / Resolution: 2.655 Å

PDB-4krn:
Nanobody/VHH domain EgA1
Method: X-RAY DIFFRACTION / Resolution: 1.553 Å

PDB-4kro:
Nanobody/VHH domain EgA1 in complex with the extracellular region of EGFR
Method: X-RAY DIFFRACTION / Resolution: 3.054 Å

PDB-4krp:
Nanobody/VHH domain 9G8 in complex with the extracellular region of EGFR
Method: X-RAY DIFFRACTION / Resolution: 2.823 Å

Chemicals

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-IOD:
IODIDE ION

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

Source
  • lama glama (llama)
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsTRANSFERASE/IMMUNE SYSTEM / cell surface receptor / glycoprotein / nanobody / VHH domain / Camelid VH domain / antibody / antigen / antibody complex / TRANSFERASE-IMMUNE SYSTEM complex / IMMUNE SYSTEM

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