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Title | Lead Optimization of a 4-Aminopyridine Benzamide Scaffold To Identify Potent, Selective, and Orally Bioavailable TYK2 Inhibitors. |
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Journal, issue, pages | J. Med. Chem., Vol. 56, Page 4521-4536, Year 2013 |
Publish date | Aug 8, 2012 (structure data deposition date) |
Authors | Liang, J. / van Abbema, A. / Balazs, M. / Barrett, K. / Berezhkovsky, L. / Blair, W. / Chang, C. / Delarosa, D. / Devoss, J. / Driscoll, J. ...Liang, J. / van Abbema, A. / Balazs, M. / Barrett, K. / Berezhkovsky, L. / Blair, W. / Chang, C. / Delarosa, D. / Devoss, J. / Driscoll, J. / Eigenbrot, C. / Ghilardi, N. / Gibbons, P. / Halladay, J. / Johnson, A. / Kohli, P.B. / Lai, Y. / Liu, Y. / Lyssikatos, J. / Mantik, P. / Menghrajani, K. / Murray, J. / Peng, I. / Sambrone, A. / Shia, S. / Shin, Y. / Smith, J. / Sohn, S. / Tsui, V. / Ultsch, M. / Wu, L.C. / Xiao, Y. / Yang, W. / Young, J. / Zhang, B. / Zhu, B.Y. / Magnuson, S. |
External links | J. Med. Chem. / PubMed:23668484 |
Methods | X-ray diffraction |
Resolution | 2.31 - 2.5 Å |
Structure data | PDB-4gii: PDB-4gj2: PDB-4gj3: |
Chemicals | ChemComp-0X6: ChemComp-HOH: ChemComp-0XH: ChemComp-0XP: |
Source |
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Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / Aminopyridine / Benzamide / Kinase / Enzyme inhibitor / Tyrosine Kinase / ATP Binding / TRANSFERASE-TRANSFERASE INHIBITOR complex |