| タイトル | Substrate and Reaction Specificity of Mycobacterium tuberculosis Cytochrome P450 CYP121: INSIGHTS FROM BIOCHEMICAL STUDIES AND CRYSTAL STRUCTURES. |
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| ジャーナル・号・ページ | J. Biol. Chem., Vol. 288, Page 17347-17359, Year 2013 |
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| 掲載日 | 2012年12月11日 (構造データの登録日) |
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著者 | Fonvielle, M. / Le Du, M.H. / Lequin, O. / Lecoq, A. / Jacquet, M. / Thai, R. / Dubois, S. / Grach, G. / Gondry, M. / Belin, P. |
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リンク | J. Biol. Chem. / PubMed:23620594 |
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| 手法 | X線回折 |
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| 解像度 | 1.2 - 1.9 Å |
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| 構造データ | PDB-4ict: Substrate and reaction specificity of Mycobacterium tuberculosis cytochrome P450 CYP121 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-4ips: Substrate and reaction specificity of Mycobacterium tuberculosis cytochrome P450 CYP121 手法: X-RAY DIFFRACTION / 解像度: 1.2 Å PDB-4ipw: Substrate and reaction specificity of Mycobacterium tuberculosis cytochrome P450 CYP121 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-4iq7: Substrate and reaction specificity of Mycobacterium tuberculosis cytochrome P450 CYP121 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-4iq9: Substrate and reaction specificity of Mycobacterium tuberculosis cytochrome P450 CYP121 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å |
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| 化合物 | ChemComp-1ED: (3S,6S)-3-benzyl-6-(4-hydroxybenzyl)piperazine-2,5-dione
ChemComp-1G4: (3S,6S)-3,6-bis(4-hydroxybenzyl)piperazin-2-one
ChemComp-1G7: (3S,6S)-3-(3,4-dihydroxybenzyl)-6-(4-hydroxybenzyl)piperazine-2,5-dione
ChemComp-1G9: (3S,6S)-3-(4-hydroxybenzyl)-6-methylpiperazine-2,5-dione
ChemComp-1GB: (3S,6S)-3-(4-hydroxybenzyl)-6-(1H-indol-3-ylmethyl)piperazine-2,5-dione
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| 由来 |  mycobacterium tuberculosis (結核菌)
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キーワード | OXIDOREDUCTASE / Protein-ligand complex / P450 fold / oxydase / cyclo-dipeptide / oxidase |
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