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TitleRedirecting P450 Eryk Specificity by Rational Site-Directed Mutagenesis.
Journal, issue, pagesBiochemistry, Vol. 52, Page 3678-, Year 2013
Publish dateJan 24, 2013 (structure data deposition date)
AuthorsMontemiglio, L.C. / Macone, A. / Ardiccioni, C. / Avella, G. / Vallone, B. / Savino, C.
External linksBiochemistry / PubMed:23597312
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-3zkp:
Structure of a mutant of P450 EryK in complex with erythromycin B.
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

ChemComp-ERB:
Erythromycin B

ChemComp-HOH:
WATER

Source
  • saccharopolyspora erythraea nrrl 2338 (bacteria)
KeywordsOXIDOREDUCTASE/ANTIBIOTIC / OXIDOREDUCTASE-ANTIBIOTIC COMPLEX / CATALYTIC DOMAIN / CYTOCHROME P-450 ENZYME SYSTEM / SUBSTRATE SPECIFICITY / MACROLIDE ANTIBIOTIC

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