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TitleDeficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease.
Journal, issue, pagesEmbo J., Vol. 32, Page 1225-1237, Year 2013
Publish dateFeb 9, 2013 (structure data deposition date)
AuthorsSharifi, R. / Morra, R. / Appel, C.D. / Tallis, M. / Chioza, B. / Jankevicius, G. / Simpson, M.A. / Matic, I. / Ozkan, E. / Golia, B. ...Sharifi, R. / Morra, R. / Appel, C.D. / Tallis, M. / Chioza, B. / Jankevicius, G. / Simpson, M.A. / Matic, I. / Ozkan, E. / Golia, B. / Schellenberg, M.J. / Weston, R. / Williams, J.G. / Rossi, M.N. / Galehdari, H. / Krahn, J. / Wan, A. / Trembath, R.C. / Crosby, A.H. / Ahel, D. / Hay, R. / Ladurner, A.G. / Timinszky, G. / Williams, R.S. / Ahel, I.
External linksEmbo J. / PubMed:23481255
MethodsX-ray diffraction
Resolution1.25 - 1.55 Å
Structure data

PDB-4j5q:
TARG1 (C6orf130), Terminal ADP-ribose Glycohydrolase 1, apo structure
Method: X-RAY DIFFRACTION / Resolution: 1.35 Å

PDB-4j5r:
TARG1 (C6orf130), Terminal ADP-ribose Glycohydrolase 1 bound to ADP-HPD
Method: X-RAY DIFFRACTION / Resolution: 1.25 Å

PDB-4j5s:
TARG1 (C6orf130), Terminal ADP-ribose Glycohydrolase 1 ADP-ribose complex
Method: X-RAY DIFFRACTION / Resolution: 1.55 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-A1R:
5'-O-[(S)-{[(S)-{[(2R,3R,4S)-3,4-DIHYDROXYPYRROLIDIN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]ADENOSINE

ChemComp-CL:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-ZZC:
[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [[(2R,3R)-2,3-DIHYDROXY-4-OXO-PENTOXY]-OXIDO-PHOSPHORYL] PHOSPHATE

ChemComp-BO4:
BORATE ION

ChemComp-SBE:
1,3,2-DIOXABOROLAN-2-OL

Source
  • homo sapiens (human)
KeywordsHYDROLASE / DNA repair / cellular signalling / macro domain / glycohydrolase / poly-ADP ribose / PARP / ADP-ribose / Cellular signaling

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