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Structure paper

TitleThe AFF4 scaffold binds human P-TEFb adjacent to HIV Tat.
Journal, issue, pagesElife, Vol. 2, Page e00327-e00327, Year 2013
Publish dateJan 3, 2013 (structure data deposition date)
AuthorsSchulze-Gahmen, U. / Upton, H. / Birnberg, A. / Bao, K. / Chou, S. / Krogan, N.J. / Zhou, Q. / Alber, T.
External linksElife / PubMed:23471103
MethodsX-ray diffraction
Resolution2.94 Å
Structure data

PDB-4imy:
The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat
Method: X-RAY DIFFRACTION / Resolution: 2.94 Å

Chemicals

ChemComp-AMP:
ADENOSINE MONOPHOSPHATE / AMP*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Transcriptional CDK9-CycT1 complex / phosphorylated / intrinsically disordered AFF4 / regulation of transcription elongation / Ser/Thr kinase / phosphorylation of PolII-CTD / DSIF / and NELF / HIV-1 Tat / Host-virus interaction / phosphoprotein / nucleus

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