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-Structure paper
Title | The molecular mechanism of substrate engagement and immunosuppressant inhibition of calcineurin. |
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Journal, issue, pages | Plos Biol., Vol. 11, Page e1001492-e1001492, Year 2013 |
Publish date | May 5, 2012 (structure data deposition date) |
![]() | Grigoriu, S. / Bond, R. / Cossio, P. / Chen, J.A. / Ly, N. / Hummer, G. / Page, R. / Cyert, M.S. / Peti, W. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 1.7 Å |
Structure data | ![]() PDB-4f0z: |
Chemicals | ![]() ChemComp-GOL: ![]() ChemComp-CA: ![]() ChemComp-HOH: |
Source |
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![]() | hydrolase/protein binding / EF-hand / phosphatase / PxIxIT / LxVP / calcium signaling / transcription regulation / T-cell activation / Calcineurin inhibition / calmodulin / RCAN / NFAT / heart / nucleus / skeletal muscle / ion channels / hydrolase-protein binding complex |