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Structure paper

TitleCrystal structures of matriptase in complex with its inhibitor hepatocyte growth factor activator inhibitor-1.
Journal, issue, pagesJ. Biol. Chem., Vol. 288, Page 11155-11164, Year 2013
Publish dateJan 16, 2013 (structure data deposition date)
AuthorsZhao, B. / Yuan, C. / Li, R. / Qu, D. / Huang, M. / Ngo, J.C.
External linksJ. Biol. Chem. / PubMed:23443661
MethodsX-ray diffraction
Resolution1.48 - 2.45 Å
Structure data

PDB-4is5:
Crystal Structure of the ligand-free inactive Matriptase
Method: X-RAY DIFFRACTION / Resolution: 1.48 Å

PDB-4isl:
Crystal Structure of the inactive Matriptase in complex with its inhibitor HAI-1
Method: X-RAY DIFFRACTION / Resolution: 2.29 Å

PDB-4isn:
Crystal Structure of Matriptase in complex with its inhibitor HAI-1
Method: X-RAY DIFFRACTION / Resolution: 2.45 Å

PDB-4iso:
Crystal Structure of Matriptase in complex with its inhibitor HAI-1
Method: X-RAY DIFFRACTION / Resolution: 2.01 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-GSH:
GLUTATHIONE

ChemComp-HOH:
WATER

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / Beta barrel / Serine protease / epithelium / hydrolase/hydrolase inhibitor / Serine protease inhibitor / hydrolase-hydrolase inhibitor complex / inhibitor

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