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TitleHyperstability and Substrate Promiscuity in Laboratory Resurrections of Precambrian Beta-Lactamases.
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 135, Page 2899-, Year 2013
Publish dateNov 27, 2012 (structure data deposition date)
AuthorsRisso, V.A. / Gavira, J.A. / Mejia-Carmona, D.F. / Gaucher, E.A. / Sanchez-Ruiz, J.M.
External linksJ. Am. Chem. Soc. / PubMed:23394108
MethodsX-ray diffraction
Resolution2.05 - 2.4 Å
Structure data

PDB-3zdj:
Ancestral (ENCA) beta-lactamase class A
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-4b88:
Ancestral (GNCA) Beta-lactamase class A
Method: X-RAY DIFFRACTION / Resolution: 2.05 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-FMT:
FORMIC ACID

Source
  • synthetic construct (others)
KeywordsHYDROLASE / ANTIBIOTIC RESISTANCE

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