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-Structure paper
Title | Development of amino-pyrimidine inhibitors of c-Jun N-terminal kinase (JNK): kinase profiling guided optimization of a 1,2,3-benzotriazole lead. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 23, Page 1486-1492, Year 2013 |
Publish date | Nov 14, 2012 (structure data deposition date) |
![]() | Palmer, W.S. / Alam, M. / Arzeno, H.B. / Chang, K.C. / Dunn, J.P. / Goldstein, D.M. / Gong, L. / Goyal, B. / Hermann, J.C. / Hogg, J.H. ...Palmer, W.S. / Alam, M. / Arzeno, H.B. / Chang, K.C. / Dunn, J.P. / Goldstein, D.M. / Gong, L. / Goyal, B. / Hermann, J.C. / Hogg, J.H. / Hsieh, G. / Jahangir, A. / Janson, C. / Jin, S. / Ursula Kammlott, R. / Kuglstatter, A. / Lukacs, C. / Michoud, C. / Niu, L. / Reuter, D.C. / Shao, A. / Silva, T. / Trejo-Martin, T.A. / Stein, K. / Tan, Y.C. / Tivitmahaisoon, P. / Tran, P. / Wagner, P. / Weller, P. / Wu, S.Y. |
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Methods | X-ray diffraction |
Resolution | 2.152 - 2.415 Å |
Structure data | ![]() PDB-4hys: ![]() PDB-4hyu: |
Chemicals | ![]() ChemComp-1BJ: ![]() ChemComp-HOH: ![]() ChemComp-1BK: |
Source |
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![]() | TRANSFERASE/TRANSFERASE INHIBITOR / kinase inhibitor / TRANSFERASE-TRANSFERASE INHIBITOR complex |