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Structure paper

TitleStructural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5.
Journal, issue, pagesCell(Cambridge,Mass. ), Vol. 152, Page 276-289, Year 2013
Publish dateAug 13, 2012 (structure data deposition date)
AuthorsWu, B. / Peisley, A. / Richards, C. / Yao, H. / Zeng, X. / Lin, C. / Chu, F. / Walz, T. / Hur, S.
External linksCell(Cambridge,Mass. ) / PubMed:23273991
MethodsX-ray diffraction
Resolution3.557 Å
Structure data

PDB-4gl2:
Structural Basis for dsRNA duplex backbone recognition by MDA5
Method: X-RAY DIFFRACTION / Resolution: 3.557 Å

Chemicals

ChemComp-ANP:
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / AMP-PNP, energy-carrying molecule analogue*YM

ChemComp-ZN:
Unknown entry

Source
  • homo sapiens (human)
KeywordsRNA BINDING PROTEIN/RNA / MDA5 / dsRNA / anti-viral signaling / RIG-I / MAVS / oligomerization / helicase / ATPase / filament formation / RNA BINDING PROTEIN-RNA complex

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