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TitleComplex-type N-glycan recognition by potent broadly neutralizing HIV antibodies.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 109, Page E3268-E3277, Year 2012
Publish dateJun 24, 2012 (structure data deposition date)
AuthorsMouquet, H. / Scharf, L. / Euler, Z. / Liu, Y. / Eden, C. / Scheid, J.F. / Halper-Stromberg, A. / Gnanapragasam, P.N. / Spencer, D.I. / Seaman, M.S. ...Mouquet, H. / Scharf, L. / Euler, Z. / Liu, Y. / Eden, C. / Scheid, J.F. / Halper-Stromberg, A. / Gnanapragasam, P.N. / Spencer, D.I. / Seaman, M.S. / Schuitemaker, H. / Feizi, T. / Nussenzweig, M.C. / Bjorkman, P.J.
External linksProc. Natl. Acad. Sci. USA / PubMed:23115339
MethodsX-ray diffraction
Resolution1.9 - 3 Å
Structure data

PDB-4fq1:
Crystal Structure of PGT121 Fab
Method: X-RAY DIFFRACTION / Resolution: 3 Å

PDB-4fq2:
Crystal Structure of 10-1074 Fab
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-4fqc:
Crystal Structure of PGT121 Fab Bound to a complex-type sialylated N-glycan
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-4fqq:
Crystal Structure of Germline Antibody PGT121-GL Fab
Method: X-RAY DIFFRACTION / Resolution: 2.42 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-144:
TRIS-HYDROXYMETHYL-METHYL-AMMONIUM

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-TAM:
TRIS(HYDROXYETHYL)AMINOMETHANE / pH buffer*YM

ChemComp-NA:
Unknown entry

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / IG FOLD / ANTI HIV / ANTIBODY

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