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TitleCofactor binding triggers a molecular switch to allosterically activate human UDP-{alpha}-D-glucose 6-dehydrogenase.
Journal, issue, pagesBiochemistry, Vol. 51, Page 9364-9374, Year 2012
Publish dateMar 27, 2012 (structure data deposition date)
AuthorsSennett, N.C. / Kadirvelraj, R. / Wood, Z.A.
External linksBiochemistry / PubMed:23106432
MethodsX-ray diffraction
Resolution2.08 Å
Structure data

PDB-4edf:
Dimeric hUGDH, K94E
Method: X-RAY DIFFRACTION / Resolution: 2.08 Å

Chemicals

ChemComp-UPG:
URIDINE-5'-DIPHOSPHATE-GLUCOSE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / oligomeric state / molecular switch / medium chain dehydrogenase / glucuronidation / MDR / Rossmann fold

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