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Structure paper

TitleInnate Immune Messenger 2-5A Tethers Human RNase L into Active High-Order Complexes.
Journal, issue, pagesCell Rep, Vol. 2, Page 902-913, Year 2012
Publish dateJul 23, 2012 (structure data deposition date)
AuthorsHan, Y. / Whitney, G. / Donovan, J. / Korennykh, A.
External linksCell Rep / PubMed:23084743
MethodsX-ray diffraction
Resolution2.4 - 2.8 Å
Structure data

PDB-4g8k:
Intact sensor domain of human RNase L in the inactive signaling state
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-4g8l:
Active state of intact sensor domain of human RNase L with 2-5A bound
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-25A:
5'-O-MONOPHOSPHORYLADENYLYL(2'->5')ADENYLYL(2'->5')ADENOSINE

Source
  • homo sapiens (human)
KeywordsHYDROLASE / Ankyrin-repeat domain / single-stranded RNA

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