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Structure paper

TitleHeterosubtypic antibody recognition of the influenza virus hemagglutinin receptor binding site enhanced by avidity.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 109, Page 17040-17045, Year 2012
Publish dateAug 16, 2012 (structure data deposition date)
AuthorsLee, P.S. / Yoshida, R. / Ekiert, D.C. / Sakai, N. / Suzuki, Y. / Takada, A. / Wilson, I.A.
External linksProc. Natl. Acad. Sci. USA / PubMed:23027945
MethodsX-ray diffraction
Resolution2.05 - 2.95 Å
Structure data

PDB-4gms:
Crystal structure of heterosubtypic Fab S139/1 in complex with influenza A H3 hemagglutinin
Method: X-RAY DIFFRACTION / Resolution: 2.95 Å

PDB-4gmt:
Crystal structure of heterosubtypic Fab S139/1
Method: X-RAY DIFFRACTION / Resolution: 2.05 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM

ChemComp-HOH:
WATER

Source
  • influenza a virus
  • mus musculus (house mouse)
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / immunoglobulin / virus attachment and entry / immune recognition / VIRAL PROTEIN-IMMUNE SYSTEM complex / IMMUNE SYSTEM / Fab / fragment antigen binding / Immunoglobulin fold

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