タイトル | Influenza virus neuraminidases with reduced enzymatic activity that avidly bind sialic Acid receptors. |
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ジャーナル・号・ページ | J. Virol., Vol. 86, Page 13371-13383, Year 2012 |
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掲載日 | 2012年9月6日 (構造データの登録日) |
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著者 | Zhu, X. / McBride, R. / Nycholat, C.M. / Yu, W. / Paulson, J.C. / Wilson, I.A. |
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リンク | J. Virol. / PubMed:23015718 |
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手法 | X線回折 |
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解像度 | 2.19 - 2.6 Å |
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構造データ | PDB-4gzo: N2 neuraminidase of A/Tanzania/205/2010 H3N2 in complex with hepes 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-4gzp: N2 Neuraminidase of A/Tanzania/205/2010 H3N2 in complex with oseltamivir carboxylate 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-4gzq: N2 neuraminidase of A/Tanzania/205/2010 H3N2 in complex with sialic acid 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-4gzs: N2 neuraminidase D151G mutant of a/Tanzania/205/2010 H3N2 in complex with hepes 手法: X-RAY DIFFRACTION / 解像度: 2.35 Å PDB-4gzt: N2 neuraminidase D151G mutant of A/Tanzania/205/2010 H3N2 in complex with oseltamivir carboxylate 手法: X-RAY DIFFRACTION / 解像度: 2.19 Å PDB-4gzw: N2 neuraminidase D151G mutant of A/Tanzania/205/2010 H3N2 in complex with avian sialic acid receptor 手法: X-RAY DIFFRACTION / 解像度: 2.45 Å PDB-4gzx: N2 neuraminidase D151G mutant of A/Tanzania/205/2010 H3N2 in complex with human sialic acid receptor 手法: X-RAY DIFFRACTION / 解像度: 2.45 Å |
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化合物 | ChemComp-EPE: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / HEPES / pH緩衝剤*YM
ChemComp-G39: (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid / オセルタミビルカルボキシラ-ト / 薬剤, 抗ウイルス剤*YM
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由来 | - influenza a virus (A型インフルエンザウイルス)
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キーワード | VIRAL PROTEIN / beta-propella / infleunza virus / neuraminidase / hemagglutinin / hemadsorption / viral infection / sialic acid receptor / influenza virus / beta-propeller |
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