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TitleSuperbinder SH2 Domains Act as Antagonists of Cell Signaling.
Journal, issue, pagesSci. Signal., Vol. 5, Page ra68-ra68, Year 2012
Publish dateMay 12, 2012 (structure data deposition date)
AuthorsKaneko, T. / Huang, H. / Cao, X. / Li, X. / Li, C. / Voss, C. / Sidhu, S.S. / Li, S.S.
External linksSci. Signal. / PubMed:23012655
MethodsX-ray diffraction
Resolution1.57 - 1.8 Å
Structure data

PDB-4f59:
Triple mutant Src SH2 domain
Method: X-RAY DIFFRACTION / Resolution: 1.71 Å

PDB-4f5a:
Triple mutant Src SH2 domain bound to phosphate ion
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-4f5b:
Triple mutant Src SH2 domain bound to phosphotyrosine
Method: X-RAY DIFFRACTION / Resolution: 1.57 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-PO4:
PHOSPHATE ION

ChemComp-PTR:
O-PHOSPHOTYROSINE

Source
  • homo sapiens (human)
KeywordsPROTEIN BINDING / SH2 domain / cell signalling / phosphotyrosine binding / phosphotyrosine

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