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Structure paper

TitleThe Structure of Human GALNS Reveals the Molecular Basis for Mucopolysaccharidosis IV A.
Journal, issue, pagesJ. Mol. Biol., Vol. 423, Page 736-751, Year 2012
Publish dateMay 28, 2012 (structure data deposition date)
AuthorsRivera-Colon, Y. / Schutsky, E.K. / Kita, A.Z. / Garman, S.C.
External linksJ. Mol. Biol. / PubMed:22940367
MethodsX-ray diffraction
Resolution2.2 - 2.81 Å
Structure data

PDB-4fdi:
The molecular basis of mucopolysaccharidosis IV A
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-4fdj:
The molecular basis of mucopolysaccharidosis IV A, complex with GalNAc
Method: X-RAY DIFFRACTION / Resolution: 2.81 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-CA:
Unknown entry

ChemComp-CIT:
CITRIC ACID

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-NGA:
2-acetamido-2-deoxy-beta-D-galactopyranose

Source
  • homo sapiens (human)
KeywordsHYDROLASE / glycoprotein / enzyme replacement therapy / sulfatase / formylglycine / N-linked glycosylation / lysosomal enzyme / carbohydrate-binding protein

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