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Structure paper

TitleParoxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility.
Journal, issue, pagesAcs Chem. Biol., Vol. 7, Page 1830-1839, Year 2012
Publish dateDec 17, 2011 (structure data deposition date)
AuthorsThal, D.M. / Homan, K.T. / Chen, J. / Wu, E.K. / Hinkle, P.M. / Huang, Z.M. / Chuprun, J.K. / Song, J. / Gao, E. / Cheung, J.Y. ...Thal, D.M. / Homan, K.T. / Chen, J. / Wu, E.K. / Hinkle, P.M. / Huang, Z.M. / Chuprun, J.K. / Song, J. / Gao, E. / Cheung, J.Y. / Sklar, L.A. / Koch, W.J. / Tesmer, J.J.
External linksAcs Chem. Biol. / PubMed:22882301
MethodsX-ray diffraction
Resolution2.07 Å
Structure data

PDB-3v5w:
Human G Protein-Coupled Receptor Kinase 2 in Complex with Soluble Gbetagamma Subunits and Paroxetine
Method: X-RAY DIFFRACTION / Resolution: 2.07 Å

Chemicals

ChemComp-8PR:
Paroxetine / medication, antidepressant, inhibitor*YM

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • bos taurus (domestic cattle)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / Inhibitor complex / Protein kinase / Beta propeller / RGS homology domain / Pleckstrin homology domain / Kinase / Signal transduction / Peripheral membrane protein / TRANSFERASE-TRANSFERASE INHIBITOR complex

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