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TitleAn Autoinhibited Noncanonical Mechanism of GTP Hydrolysis by Rheb Maintains mTORC1 Homeostasis.
Journal, issue, pagesStructure, Vol. 20, Page 1528-1539, Year 2012
Publish dateJun 10, 2011 (structure data deposition date)
AuthorsMazhab-Jafari, M.T. / Marshall, C.B. / Ishiyama, N. / Ho, J. / Di Palma, V. / Stambolic, V. / Ikura, M.
External linksStructure / PubMed:22819219
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-3sea:
Structure of Rheb-Y35A mutant in GDP- and GMPPNP-bound forms
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-GNP:
PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER / GppNHp, GMPPNP, energy-carrying molecule analogue*YM

ChemComp-ACT:
ACETATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / globular

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