タイトル | Structure-guided directed evolution of highly selective p450-based magnetic resonance imaging sensors for dopamine and serotonin. |
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ジャーナル・号・ページ | J. Mol. Biol., Vol. 422, Page 245-262, Year 2012 |
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掲載日 | 2012年2月21日 (構造データの登録日) |
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著者 | Brustad, E.M. / Lelyveld, V.S. / Snow, C.D. / Crook, N. / Jung, S.T. / Martinez, F.M. / Scholl, T.J. / Jasanoff, A. / Arnold, F.H. |
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リンク | J. Mol. Biol. / PubMed:22659321 |
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手法 | X線回折 |
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解像度 | 1.45 - 2 Å |
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構造データ | PDB-4dtw: cytochrome P450 BM3h-8C8 MRI sensor bound to serotonin 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-4dty: cytochrome P450 BM3h-8C8 MRI sensor, no ligand 手法: X-RAY DIFFRACTION / 解像度: 1.45 Å PDB-4dtz: cytochrome P450 BM3h-8C8 MRI sensor bound to dopamine 手法: X-RAY DIFFRACTION / 解像度: 1.55 Å PDB-4du2: cytochrome P450 BM3h-B7 MRI sensor bound to dopamine 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-4dua: cytochrome P450 BM3h-9D7 MRI sensor, no ligand 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-4dub: cytochrome P450 BM3h-9D7 MRI sensor bound to dopamine 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-4duc: cytochrome P450 BM3h-2G9 MRI sensor, no ligand 手法: X-RAY DIFFRACTION / 解像度: 1.92 Å PDB-4dud: cytochrome P450 BM3h-2G9C6 MRI sensor, no ligand 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-4due: cytochrome P450 BM3h-2G9C6 MRI sensor bound to serotonin 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-4duf: cytochrome P450 BM3h-2G9 MRI sensor bound to serotonin 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å |
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化合物 | |
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由来 | - bacillus megaterium (バクテリア)
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キーワード | OXIDOREDUCTASE / cytochrome P450 / MRI contrast sensor / directed evolution |
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