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TitleCrystal structures of protease nexin-1 in complex with heparin and thrombin suggest a 2-step recognition mechanism.
Journal, issue, pagesBlood, Vol. 120, Page 459-467, Year 2012
Publish dateFeb 28, 2012 (structure data deposition date)
AuthorsLi, W. / Huntington, J.A.
External linksBlood / PubMed:22618708
MethodsX-ray diffraction
Resolution2.35 - 2.8 Å
Structure data

PDB-4dy0:
Crystal structure of native protease nexin-1 with heparin
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

PDB-4dy7:
Crystal structures of protease nexin-1 in complex with S195A thrombin
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-ACT:
ACETATE ION

ChemComp-CA:
Unknown entry

ChemComp-NA:
Unknown entry

Source
  • homo sapiens (human)
KeywordsHYDROLASE INHIBITOR / serpin / protease inhibitor / thrombin / cell surface / HYDROLASE/HYDROLASE INHIBITOR / protease / heparin / HYDROLASE-HYDROLASE INHIBITOR complex

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