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-Structure paper
Title | Identification of Imidazo-Pyrrolopyridines as Novel and Potent JAK1 Inhibitors. |
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Journal, issue, pages | J. Med. Chem., Vol. 55, Page 5901-5921, Year 2012 |
Publish date | Mar 13, 2012 (structure data deposition date) |
![]() | Kulagowski, J.J. / Blair, W. / Bull, R.J. / Chang, C. / Deshmukh, G. / Dyke, H.J. / Eigenbrot, C. / Ghilardi, N. / Gibbons, P. / Harrison, T.K. ...Kulagowski, J.J. / Blair, W. / Bull, R.J. / Chang, C. / Deshmukh, G. / Dyke, H.J. / Eigenbrot, C. / Ghilardi, N. / Gibbons, P. / Harrison, T.K. / Hewitt, P.R. / Liimatta, M. / Hurley, C.A. / Johnson, A. / Johnson, T. / Kenny, J.R. / Bir Kohli, P. / Maxey, R.J. / Mendonca, R. / Mortara, K. / Murray, J. / Narukulla, R. / Shia, S. / Steffek, M. / Ubhayakar, S. / Ultsch, M. / van Abbema, A. / Ward, S.I. / Waszkowycz, B. / Zak, M. |
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Methods | X-ray diffraction |
Resolution | 1.86 - 2.25 Å |
Structure data | ![]() PDB-4e4l: ![]() PDB-4e4m: ![]() PDB-4e4n: ![]() PDB-4e5w: ![]() PDB-4e6d: ![]() PDB-4e6q: |
Chemicals | ![]() ChemComp-0NH: ![]() ChemComp-HOH: ![]() ChemComp-0NL: ![]() ChemComp-0NT: ![]() ChemComp-PEG: ![]() ChemComp-0NU: ![]() ChemComp-GOL: ![]() ChemComp-0NV: |
Source |
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![]() | TRANSFERASE/TRANSFERASE INHIBITOR / o-phosphotyrosine / TRANSFERASE-TRANSFERASE INHIBITOR complex / JAK1 / kinase domain / kinase / JAK2 / transferase / phosphorylation |