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TitleThe PHD and chromo domains regulate the ATPase activity of the human chromatin remodeler CHD4.
Journal, issue, pagesJ Mol Biol, Vol. 422, Issue 1, Page 3-17, Year 2012
Publish dateSep 7, 2012
AuthorsAleksandra A Watson / Pravin Mahajan / Haydyn D T Mertens / Michael J Deery / Wenchao Zhang / Peter Pham / Xiuxia Du / Till Bartke / Wei Zhang / Christian Edlich / Georgina Berridge / Yun Chen / Nicola A Burgess-Brown / Tony Kouzarides / Nicola Wiechens / Tom Owen-Hughes / Dmitri I Svergun / Opher Gileadi / Ernest D Laue /
PubMed AbstractThe NuRD (nucleosome remodeling and deacetylase) complex serves as a crucial epigenetic regulator of cell differentiation, proliferation, and hematopoietic development by coupling the deacetylation ...The NuRD (nucleosome remodeling and deacetylase) complex serves as a crucial epigenetic regulator of cell differentiation, proliferation, and hematopoietic development by coupling the deacetylation and demethylation of histones, nucleosome mobilization, and the recruitment of transcription factors. The core nucleosome remodeling function of the mammalian NuRD complex is executed by the helicase-domain-containing ATPase CHD4 (Mi-2β) subunit, which also contains N-terminal plant homeodomain (PHD) and chromo domains. The mode of regulation of chromatin remodeling by CHD4 is not well understood, nor is the role of its PHD and chromo domains. Here, we use small-angle X-ray scattering, nucleosome binding ATPase and remodeling assays, limited proteolysis, cross-linking, and tandem mass spectrometry to propose a three-dimensional structural model describing the overall shape and domain interactions of CHD4 and discuss the relevance of these for regulating the remodeling of chromatin by the NuRD complex.
External linksJ Mol Biol / PubMed:22575888 / PubMed Central
MethodsSAS (X-ray synchrotron)
Structure data

SASDA85:
CHD4 (PP-CC-AH-D) (Human Chromatin Remodeler CHD4 (363-1353))
Method: SAXS/SANS

SASDA95:
CHD4 (CC-AH-D) (Human Chromatin Remodeler CHD4 (494-1353))
Method: SAXS/SANS

SASDAA5:
CHD4 (AH) (Human Chromatin Remodeler CHD4 (685-1233))
Method: SAXS/SANS

SASDAB5:
CHD4 (PP-CC) (Human Chromatin Remodeler CHD4 (363-682))
Method: SAXS/SANS

Source
  • Homo sapiens (human)

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