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Structure paper

TitleFunctional determinants of human enteric {alpha}-defensin HD5: crucial role for hydrophobicity at dimer interface.
Journal, issue, pagesJ. Biol. Chem., Vol. 287, Page 21615-21627, Year 2012
Publish dateMar 19, 2012 (structure data deposition date)
AuthorsRajabi, M. / Ericksen, B. / Wu, X. / de Leeuw, E. / Zhao, L. / Pazgier, M. / Lu, W.
External linksJ. Biol. Chem. / PubMed:22573326
MethodsX-ray diffraction
Resolution1.7 - 2.75 Å
Structure data

PDB-4e82:
Crystal structure of monomeric variant of human alpha-defensin 5, HD5 (Glu21EMe mutant)
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-4e83:
Crystal structure of human alpha-defensin 5, HD5 (Leu29NLe mutant)
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-4e86:
Crystal structure of human alpha-defensin 5, HD5 (Leu29Aba mutant)
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-CL:
Unknown entry

Source
  • homo sapiens (human)
KeywordsANTIMICROBIAL PROTEIN / monomeric variant / antimicrobial peptide / Glu21 methylation / Paneth cells / beta-sheet structure / Leu29Nle mutant / mutant Leu29Aba / beta-sheet

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