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Structure paper

TitleHemostatic effect of a monoclonal antibody mAb 2021 blocking the interaction between FXa and TFPI in a rabbit hemophilia model.
Journal, issue, pagesBlood, Vol. 119, Page 5871-5878, Year 2012
Publish dateFeb 21, 2012 (structure data deposition date)
AuthorsHilden, I. / Lauritzen, B. / Sorensen, B.B. / Clausen, J.T. / Jespersgaard, C. / Krogh, B.O. / Bowler, A.N. / Breinholt, J. / Gruhler, A. / Svensson, L.A. ...Hilden, I. / Lauritzen, B. / Sorensen, B.B. / Clausen, J.T. / Jespersgaard, C. / Krogh, B.O. / Bowler, A.N. / Breinholt, J. / Gruhler, A. / Svensson, L.A. / Petersen, H.H. / Petersen, L.C. / Balling, K.W. / Hansen, L. / Hermit, M.B. / Egebjerg, T. / Friederichsen, B. / Ezban, M. / Bjorn, S.E.
External linksBlood / PubMed:22563084
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-4dtg:
Hemostatic effect of a monoclonal antibody mAb 2021 blocking the interaction between FXa and TFPI in a rabbit hemophilia model
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsBLOOD CLOTTING INHIBITOR/IMMUNE SYSTEM / antibody / inhibitor / blood coagulation / BLOOD CLOTTING INHIBITOR-IMMUNE SYSTEM complex

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