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TitleStructural basis for cisplatin DNA damage tolerance by human polymerase {eta} during cancer chemotherapy.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 19, Page 628-632, Year 2012
Publish dateMar 28, 2012 (structure data deposition date)
AuthorsUmmat, A. / Rechkoblit, O. / Jain, R. / Roy Choudhury, J. / Johnson, R.E. / Silverstein, T.D. / Buku, A. / Lone, S. / Prakash, L. / Prakash, S. / Aggarwal, A.K.
External linksNat. Struct. Mol. Biol. / PubMed:22562137
MethodsX-ray diffraction
Resolution2.32 Å
Structure data

PDB-4eey:
Crystal structure of human DNA polymerase eta in ternary complex with a cisplatin DNA adduct
Method: X-RAY DIFFRACTION / Resolution: 2.32 Å

Chemicals

ChemComp-DCP:
2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE

ChemComp-MG:
Unknown entry

ChemComp-CPT:
Cisplatin / medication, chemotherapy*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/DNA / DNA replication / DNA repair / TRANSFERASE-DNA complex

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