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Structure paper

TitleTwo Crucial Early Steps in RNA Synthesis by the Hepatitis C Virus Polymerase Involve a Dual Role of Residue 405.
Journal, issue, pagesJ. Virol., Vol. 86, Page 7107-, Year 2012
Publish dateJan 2, 2012 (structure data deposition date)
AuthorsScrima, N. / Caillet-Saguy, C. / Ventura, M. / Harrus, D. / Astier-Gin, T. / Bressanelli, S.
External linksJ. Virol. / PubMed:22532694
MethodsX-ray diffraction
Resolution1.8 - 2.41 Å
Structure data

PDB-4adp:
HCV-J6 NS5B POLYMERASE V405I MUTANT
Method: X-RAY DIFFRACTION / Resolution: 1.902 Å

PDB-4aep:
HCV-JFH1 NS5B POLYMERASE STRUCTURE AT 1.8 ANGSTROM
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-4aex:
HCV-JFH1 NS5B POLYMERASE STRUCTURE AT 2.4 ANGSTROM in a primitive orthorhombic space group
Method: X-RAY DIFFRACTION / Resolution: 2.41 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-PO4:
PHOSPHATE ION

Source
  • hepatitis c virus
KeywordsTRANSFERASE / HEPACIVIRUS / NONSTRUCTURAL PROTEINS / REPLICATION / RNA-DIRECTED RNA POLYMERASE / RDRP / DE NOVO INITIATION / PRIMING

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