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Structure paper

TitleStructure of hepatitis C virus polymerase in complex with primer-template RNA.
Journal, issue, pagesJ. Virol., Vol. 86, Page 6503-6511, Year 2012
Publish dateMar 16, 2012 (structure data deposition date)
AuthorsMosley, R.T. / Edwards, T.E. / Murakami, E. / Lam, A.M. / Grice, R.L. / Du, J. / Sofia, M.J. / Furman, P.A. / Otto, M.J.
External linksJ. Virol. / PubMed:22496223
MethodsX-ray diffraction
Resolution2.5 - 3 Å
Structure data

PDB-4e76:
Apo crystal structure of HCV NS5B genotype 2A JFH-1 isolate with beta hairpin loop deletion
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-4e78:
Crystal structure of a product state assembly of HCV NS5B genotype 2a JFH-1 isolate with beta hairpin loop deletion bound to primer-template RNA with 3'-dG
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-4e7a:
Crystal structure of a product state assembly of HCV NS5B genotype 2a JFH-1 isolate with beta hairpin deletion bound to primer-template RNA with a 2',3'-ddC
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • hepatitis c virus
KeywordsVIRAL PROTEIN / TRANSFERASE / RDRP / loopless DELTA8 / Flaviviridae / hepatitis C virus / TRANSFERASE/RNA / ternary complex / product complex / TRANSFERASE-RNA complex

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