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Structure paper

TitleExploiting a natural conformational switch to engineer an interleukin-2 'superkine'
Journal, issue, pagesNature, Vol. 484, Page 529-533, Year 2012
Publish dateJan 12, 2011 (structure data deposition date)
AuthorsLevin, A.M. / Bates, D.L. / Ring, A.M. / Krieg, C. / Lin, J.T. / Su, L. / Moraga, I. / Raeber, M.E. / Bowman, G.R. / Novick, P. ...Levin, A.M. / Bates, D.L. / Ring, A.M. / Krieg, C. / Lin, J.T. / Su, L. / Moraga, I. / Raeber, M.E. / Bowman, G.R. / Novick, P. / Pande, V.S. / Fathman, C.G. / Boyman, O. / Garcia, K.C.
External linksNature / PubMed:22446627
MethodsX-ray diffraction
Resolution3.1 - 3.802 Å
Structure data

PDB-3qaz:
IL-2 mutant D10 ternary complex
Method: X-RAY DIFFRACTION / Resolution: 3.802 Å

PDB-3qb1:
Interleukin-2 mutant D10
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN/Cytokine / cytokine receptor signaling complex / SIGNALING PROTEIN-Cytokine complex / CYTOKINE / high affinity IL-2 cytokine

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