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-Structure paper
Title | Exploiting a natural conformational switch to engineer an interleukin-2 'superkine' |
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Journal, issue, pages | Nature, Vol. 484, Page 529-533, Year 2012 |
Publish date | Jan 12, 2011 (structure data deposition date) |
![]() | Levin, A.M. / Bates, D.L. / Ring, A.M. / Krieg, C. / Lin, J.T. / Su, L. / Moraga, I. / Raeber, M.E. / Bowman, G.R. / Novick, P. ...Levin, A.M. / Bates, D.L. / Ring, A.M. / Krieg, C. / Lin, J.T. / Su, L. / Moraga, I. / Raeber, M.E. / Bowman, G.R. / Novick, P. / Pande, V.S. / Fathman, C.G. / Boyman, O. / Garcia, K.C. |
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Methods | X-ray diffraction |
Resolution | 3.1 - 3.802 Å |
Structure data | ![]() PDB-3qaz: ![]() PDB-3qb1: |
Chemicals | ![]() ChemComp-NAG: |
Source |
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![]() | SIGNALING PROTEIN/Cytokine / cytokine receptor signaling complex / SIGNALING PROTEIN-Cytokine complex / CYTOKINE / high affinity IL-2 cytokine |