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TitleDiscovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152).
Journal, issue, pagesJ. Med. Chem., Vol. 55, Page 4101-4113, Year 2012
Publish dateNov 30, 2011 (structure data deposition date)
AuthorsFlygare, J.A. / Beresini, M. / Budha, N. / Chan, H. / Chan, I.T. / Cheeti, S. / Cohen, F. / Deshayes, K. / Doerner, K. / Eckhardt, S.G. ...Flygare, J.A. / Beresini, M. / Budha, N. / Chan, H. / Chan, I.T. / Cheeti, S. / Cohen, F. / Deshayes, K. / Doerner, K. / Eckhardt, S.G. / Elliott, L.O. / Feng, B. / Franklin, M.C. / Reisner, S.F. / Gazzard, L. / Halladay, J. / Hymowitz, S.G. / La, H. / Lorusso, P. / Maurer, B. / Murray, L. / Plise, E. / Quan, C. / Stephan, J.P. / Young, S.G. / Tom, J. / Tsui, V. / Um, J. / Varfolomeev, E. / Vucic, D. / Wagner, A.J. / Wallweber, H.J. / Wang, L. / Ware, J. / Wen, Z. / Wong, H. / Wong, J.M. / Wong, M. / Wong, S. / Yu, R. / Zobel, K. / Fairbrother, W.J.
External linksJ. Med. Chem. / PubMed:22413863
MethodsX-ray diffraction
Resolution1.71 - 1.79 Å
Structure data

PDB-3uw4:
Crystal structure of cIAP1 BIR3 bound to GDC0152
Method: X-RAY DIFFRACTION / Resolution: 1.79 Å

PDB-3uw5:
Crystal structure of the BIR domain of MLIAP bound to GDC0152
Method: X-RAY DIFFRACTION / Resolution: 1.71 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
KeywordsApoptosis Inhibitor / BIR domain

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