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Structure paper

TitleAtomic view of a toxic amyloid small oligomer.
Journal, issue, pagesScience, Vol. 335, Page 1228-1231, Year 2012
Publish dateJun 15, 2011 (structure data deposition date)
AuthorsLaganowsky, A. / Liu, C. / Sawaya, M.R. / Whitelegge, J.P. / Park, J. / Zhao, M. / Pensalfini, A. / Soriaga, A.B. / Landau, M. / Teng, P.K. ...Laganowsky, A. / Liu, C. / Sawaya, M.R. / Whitelegge, J.P. / Park, J. / Zhao, M. / Pensalfini, A. / Soriaga, A.B. / Landau, M. / Teng, P.K. / Cascio, D. / Glabe, C. / Eisenberg, D.
External linksScience / PubMed:22403391
MethodsX-ray diffraction
Resolution1.4016 - 2.807 Å
Structure data

PDB-3sgm:
Bromoderivative-2 of amyloid-related segment of alphaB-crystallin residues 90-100
Method: X-RAY DIFFRACTION / Resolution: 1.7006 Å

PDB-3sgn:
Bromoderivative-8 of amyloid-related segment of alphaB-crystallin residues 90-100
Method: X-RAY DIFFRACTION / Resolution: 2.807 Å

PDB-3sgo:
Amyloid-related segment of alphaB-crystallin residues 90-100
Method: X-RAY DIFFRACTION / Resolution: 2.557 Å

PDB-3sgp:
Amyloid-related segment of alphaB-crystallin residues 90-100 mutant V91L
Method: X-RAY DIFFRACTION / Resolution: 1.4016 Å

PDB-3sgr:
Tandem repeat of amyloid-related segment of alphaB-crystallin residues 90-100 mutant V91L
Method: X-RAY DIFFRACTION / Resolution: 2.17 Å

PDB-3sgs:
Amyloid-related segment of alphaB-crystallin residues 95-100
Method: X-RAY DIFFRACTION / Resolution: 1.703 Å

Chemicals

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

ChemComp-HOH:
WATER

ChemComp-MRD:
(4R)-2-METHYLPENTANE-2,4-DIOL / precipitant*YM

Source
  • homo sapiens (human)
KeywordsPROTEIN FIBRIL / amyloid / amyloid oligomer / beta cylindrin / amyloid fibril

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